HORDB

ID: hor004205
Uniprot ID: P20757
Protein name: Angiotensin 1-5
Gene name: AGT
Organism: Ovis aries (Sheep)
Family: Serpin family
Source: Animal
Expression: Expressed by the liver and secreted in plasma.
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0004867 serine-type endopeptidase inhibitor activity
GO BP: GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin; GO:0010718 positive regulation of epithelial to mesenchymal transition; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance; GO:1901394 positive regulation of transforming growth factor beta1 activation
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: DRVYI
Length: 5(25-29)
Propeptide: MAPAGLSLGATILCLLAWAGLAAGDRVYIHPFHLLVHSKSNCDQLEKPSVETPADPTLTPVPIQTKSSPVDEEALWEQLVRATEKLEAEDRLRASEVGLLLNFMGFHVYKTLSETWSVASGLVFSPVALFSTLTSFYTGALDPTASRLQAFLGVPGEGQGCTSRLDGRKVLSSLQTIQGLLVAPGGASSQARLLLSTVVGLFTAPGLHLKQPFVQGLSSFAPITLPRSLDLSTDPNLAAEKINRFMHSATGWNMG
Signal peptide: MAPAGLSLGATILCLLAWAGLAAG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
Mechanism: NA
Cross BBB: NA
Target: AGTR2
Target Unid: Q28929
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004205_AF2.pdb

hor004205_ESM.pdb

Mass:	73629	Formula:	C30H48N8O9
Absent amino acids:	ACEFGHKLMNPQSTW	Common amino acids:	DIRVY
pI:	6.34	Basic residues:	1
Polar residues:	1	Hydrophobic residues:	2
Hydrophobicity:	-12	Boman Index:	-1482
Half-Life:	1.1 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	136
Instability Index:	-2216	Extinction Coefficient cystines:	1490
Absorbance 280nm:	372.5